Spurs have a tough task now to qualify from the group
Tottenham Hotspur have suffered a Champions League setback after a 1-0 loss to Bayer Leverkusen at Wembley.
The result leaves Mauricio Pochettino's team third in Group E on four points after four matches as the German side leapfrog them into second on six points.
Kevin Kampl scored the only goal of the game from close range to give Leverkusen the win.
Monaco lead the group on eight points after defeating CSKA Moscow 3-0.
Meanwhile, Leicester City remain top of Group G by three points after a scoreless draw in Denmark against FC Copenhagen.
Second placed FC Porto closed the game by beating Club Brugge 1-0 at the Dragao.
In the eye-catching result of the night, Legia Warsaw, who knocked Dundalk out at the Champions League playoff stage held holders Real Madrid 3-3, with Gareth Bale opening the scoring with a fantastic long-range effort for the La Liga side.