There will be emotional scenes this evening at Maginn Park as Derry City return to action for the first time since the passing of their captain, Ryan McBride.
Kenny Shiels' side host Bray Wanderers who come off the back of consecutive defeats against Limerick FC and Sligo Rovers and have lost three of their last four games.
Dundalk will be hoping to eat into Cork City's six-point lead at the top of the Premier Division when they take on Drogheda United at Oriel Park.
Cork City have won six out of six so far this season and will look to make that seven when they travel to Market's Field to take on a resurgent Limerick FC.
There's a clash at the bottom of the table when basement club Galway United welcome second-last Sligo Rovers to Eamonn Deacy Park.
In the Dublin Derby, Bohemians host St Patrick's Athletic at Dalymount Park. In the night's other game, Finn Harps travel to Tallaght Stadium to take on Shamrock Rovers.
This week on Newstalk's SSE Airtricity League Podcast, Daniel Kelly and Oisin Langan remember Bohemian FC legend Jackie Jameson.
You can also catch up on Mick Cooke's League of Ireland predictions here.
Premier Division
Dundalk v Drogheda United, Oriel Park (7.30pm)
Derry v Bray Wanderers, Maginn Park (7.45pm)
Limerick v Cork City, Markets Field (7.45pm)
Galway United v Sligo Rovers, Eamonn Deacy Park (7.45pm)
Bohemians v St Patrick's Athletic, Dalymount Park (7.45pm)
Shamrock Rovers v Finn Harps, Tallaght Stadium (8pm)
First Division
Athlone Town v Cabinteely FC, Athlone Town Stadium (7.45pm)
Shelbourne v Wexford FC, Tolka Park (7.45pm)
Cobh Ramblers v UCD, St. Colman's Park (Saturday 1/4, 7.15pm)
Longford Town v Waterford FC, City Calling Stadium, (Saturday 1/4, 7.30pm)
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