League leaders Cork City look set to make it 12 wins from 12 on Friday evening when they welcome Finn Harps to Turner's Cross.
John Caulfield's side have conceded just five goals this season in the Premier Division and can extend their lead at the top of the table to 15 points with victory.
Hot on their trail are Bray Wanderers who can move to above Dundalk into second with a victory over second from bottom St. Patrick's Athletic at the Carlisle Grounds.
Speaking to Newstalk.com this week, Bray defender Keith Buckley says his side need to improve defensively if they are going to challenge for European places.
Dundalk face a potentially tricky trip to Tallaght on Friday night, but come up against a Shamrock Rovers side struggling to find consistency.
Speaking on Newstalk's SSE Airtricity League Podcast, Rovers boss Stephen Bradley discussed his side's form and the pressures that come with trying to pick up immediate results.
Meanwhile, Derry City can climb back into the top four with a win against Bohemians at Maginn Park.
Galway United will look to make it consecutive wins when they travel to Drogheda United on Friday night. A win could take Galway off the bottom of the table and out of the relegation zone.
Elsewhere, Limerick FC travel to the Showgrounds to face Sligo Rovers on Satruday night.
You can read all of Mick Cooke's League of Ireland predictions for this weekend here.
Also on this week's Team 33, former Chelsea defender Paddy Mulligan remembered his part in an all-Ireland XI clash with world champions, Brazil, in 1973.
Premier Division
Cork City vs. Finn Harps, Turner's Cross (7.45pm)
Bray Wanderers vs. St. Patrick's Athletic, Carlisle Grounds (7.45pm)
Derry City vs. Bohemians, Maginn Park (7.45pm)
Drogheda United vs. Galway United, United Park (7.45pm)
Shamrock Rovers vs. Dundalk, Tallaght Stadium (8pm)
Sligo Rovers vs. Limerick FC, The Showgrounds (Saturday 6/5, 7.45pm)
First Division
Athlone Town vs. Cobh Ramblers, Athlone Town Stadium (7.45pm)
UCD vs. Wexford FC, The UCD Bowl, (7.45pm)
Waterford FC vs. Shelbourne, Regional Sports Centre (7.45pm)
Cabinteely vs. Longford Town, Stradbrook (Saturday 6/5, 7pm)
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