Cian Healy starts, while Rhys Ruddock will captain the side
Ulster's Jacob Stockdale will make his senior Ireland debut this weekend as Joe Schmidt's side take on USA in New Jersey.
Schmidt begins his summer tour in the States and will take the chance to try out some new faces, with many of his first team regulars away on Lions duty in the southern hemisphere.
Cian Healy will start the game and Rhys Ruddock will captain the side at Red Bull Arena. On the bench, Ireland include four uncapped players in James Ryan, Rory Scannell, Dave Heffernan and Andrew Porter.
Schmidt has opted for a youthful approach to proceedings, with Joey Carbery, Garry Ringrose and Josh van der Flier all make the starting XV.