Ireland's autumn scheduled has been significantly lightened with the cancellation of their test with the USA in Las Vegas.
The sides were due to meet at Allegiant Stadium on Saturday, October 30.
The test was to precede Ireland's three matches of the Guinness Series at the Aviva Stadium in November.
However, continued travel restrictions have forced the game to be scrapped.
Ireland thrashed the Eagles 71-10 when the sides met in front of a limited crowd at the Aviva back in July. The USA had stepped in after Ireland's proposed tour of Fiji fell through, also owing to travel curtailments.
With border restrictions in place until November 1, the IRFU and USA Rugby have been forced to scrap the Las Vegas test.
It's hoped the match can be rearranged for October 2022.
"It’s regrettable that the game won’t be going ahead this October," said outgoing IRFU chief executive, Philip Browne, "From an IRFU point of view, the match presented the Irish team with another valuable Test match and the opportunity to experience the atmosphere at the impressive Allegiant Stadium.
"I am sure Irish supporters were excited at the prospect of seeing the team play in Las Vegas. Irish Rugby is committed to enhancing its connection with the Irish diaspora in the US and has played memorable fixtures in Chicago and New Jersey in recent seasons as we further expand the Irish Rugby brand globally.
"We are very supportive at looking at rescheduling the fixture next year.”
USA Rugby CEO Ross Young added, "“We’re obviously extremely disappointed to hear this match is unable to take place as scheduled in 2021.
“Learning about the impact of ever-changing travel restrictions was devastating, but unfortunately an all-too-common consequence for international sport over the past year and a half.
"Knowing that our Men’s Eagles will still have the chance to host Ireland in a venue like Allegiant Stadium next year is encouraging and we look forward to seeing that event being confirmed and ultimately delivered as a bigger and better experience for everyone.”