The Irish Women's team has been named ahead of Saturday's game against England which also takes place in Twickenham.
Head Coach Tom Tierney has made several changes from the defeat to France last time out.
Flanker Ciara Griffin earns her first Six Nations start as Heather O'Brien slips to the bench while Nora Stapleton gets the nod at out-half instead of Nikki Caughey.
"While the result in France didn't go our way, I thought there were a lot of positives to take from that game and we will be looking to carry them this fixture. We made too many unforced errors in Perpignan, so if we can rectify that I think we have got a very good chance on Saturday," said head coach Tom Tierney as he announced the team.
Ireland Women v England Women,
Twickenham, Saturday 27th February, 7.15pm
15. Niamh Briggs (UL. Bohemians / Munster)
14. Elise O'Byrne-White (Old Belvedere / Leinster)
13. Aine Donnelly (Cill Dara / Leinster)
12. Sene Naoupu (Galwegians / Connacht)
11. Mairead Coyne (Galwegians / Connacht)
10. Nora Stapleton (Old Belvedere / Leinster)
9. Larissa Muldoon (Skewen)
1. Ruth O'Reilly (Galwegians / Connacht)
2. Cliodhna Moloney (Railway Union / Leinster)
3. Ailis Egan (Old Belvedere / Leinster)
4. Sophie Spence (Old Belvedere / Leinster)
5. Marie-Louise Reilly (Old Belvedere / Leinster)
6. Ciara Griffin (Tralee / Munster)
7. Claire Molloy (Bristol)
8. Paula Fitzpatrick (Toulouse)
Replacements
16. Zoe Grattage (Tralee / Munster)
17. Fiona Hayes (UL Bohemians / Munster)
18. Fiona Reidy (UL Bohemians / Munster)
19. Ciara Cooney (Railway Union / Leinster)
20. Heather O'Brien (Toulouse)
21. Mary Healy (Galwegians / Connacht)
22. Nikki Caughey (Railway Union / Ulster)
23. Jackie Shiels (Richmond)
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