Bruno Fernandes has been left out of Manchester United's starting team ahead of this evening's match away to West Ham.
Ole Gunnar Solskjaer has gone for a midfield of Paul Pogba, Donny van de Beek and Scott McTominay, while Fernandes drops to the bench.
David Moyes' West Ham are in a rich vein of form as his former employers arrive to the London Stadium.
The Hammers have been the surprise package of the season so far, and a win this evening could see them rise to third in the Premier League table.
Moyes' side have lost just one of their last seven games during a period that has seen wins against Fulham, Aston Villa, Sheffield United and Leicester City, and draws against Liverpool and Manchester City.
Meanwhile, Manchester United make the trip to London after a deflating home loss to Paris Saint Germain this week.
Solskjaer's side have been in better form domestically, racking up wins against West Brom, Southampton and Everton since their defeat to Arsenal at the beginning of November.
The Hammers defeated United 2-0 in this fixture last season thanks to goals from Andriy Yarmolenko and Aaron Cresswell
Kick-off is at 5.30pm at the London Stadium.