Goals from Daniel Sturridge and Adam Lallana saw Liverpool come from behind to beat Crystal Palace 2-1 at Selhurst Park, and in the process book their place in the FA Cup sixth round.
For the second consecutive round in this season's FA Cup, Blackburn claimed a Premier League scalp at Ewood Park.
Josh King scored a hat-trick in a 4-1 defeat of Stoke. Mark Hughes' side also had Geoff Cameron sent off just before half time.
32-year old Yakubu, meanwhile, got the winner for Reading, who were 2-1 victors away to Derby.
Earlier, West Brom breezed into the sixth round, with a 4-0 pasting of West Ham at the Hawthorns.
Brown Ideye struck twice, and West Ham had substitute Morgan Amalfitano sent off there.
Full-time scores:
West Brom 4-0 West Ham
(WB: Ideye 20', Morrison 42', Ideye 57', Berahino 72')
Blackburn 4-1 Stoke
(B: King 36', 50', 55', Gestede 45 + 6'// S: Crouch 10')
Derby 1-2 Reading
(D: Bent 61' // R: Robson-Kanu 53', Yakubu 82')
Crystal Palace 1-2 Liverpool
(CP: Campbell 15' // L: Sturridge 49', Lallana 58')
Download the brand new OffTheBall App in the Play Store & App Store right now! We've got you covered!
Subscribe to OffTheBall's YouTube channel for more videos, like us on Facebook or follow us on Twitter for the latest sporting news and content.
