Ireland have been forced into a late change ahead of Sunday's Guinness Six Nations match against England at Twickenham.
Devin Toner comes into the second-row to replace Iain Henderson - who has been ruled out for family reasons.
Veteran Leinster lock Toner came off the bench in the recent victories against Scotland and Wales and will win his 70th cap on Sunday.
Connacht's Ultan Dillane is now among the replacements with the rest of the matchday 23 unchanged from the one named by Andy Farrell earlier this week.
England head-coach Eddie Jones, meanwhile, has made four changes to his starting line-up for Sunday's Guinness Six Nations clash with Ireland.
Centre Manu Tuilagi returns after injury for the match at Twickenham, with Ben Youngs replacing Willi Heinz at scrum-half.
Joe Marler comes in for Mako Vunipola - who misses the game for family reasons - and Courtney Lawes takes the place of Lewis Ludlam.
England v Ireland: Elliot Daly; Johnny May, Manu Tuilagi, Owen Farrell (captain), Joseph; George Ford, Ben Youngs; Joe Marler, Jamie George, Kyle Sinckler, Itoje, George Kruis, Courtney Lawes, Sam Underhill, Tom Curry.
Replacements: Luke Cowan-Dickie, Ellis Genge, Will Stuart, Joe Launchbury, Charlie Ewels, Ben Earl, Willi Heinz, Harry Slade.
Ireland v England: Jordan Larmour; Andrew Conway, Robbie Henshaw, Bundee Aki, Jacob Stockdale; Johnny Sexton (captain), Conor Murray; Cian Healy, Rob Herring, Tadhg Furlong, Devin Toner, James Ryan, Peter O'Mahony, Josh van der Flier, CJ Stander.
Replacements: Ronan Kelleher, Dave Kilcoyne, Andrew Porter, Ultan Dillane, Caelan Doris, John Cooney, Ross Byrne, Keith Earls.
More to follow...
Breaking: Late change to Ireland team. Iain Henderson @HendersonIain ruled out for family reasons. Devin Toner @DevinToner4 will start with Ultan Dillane @Ultan_Dillane named in the replacements.#ShoulderToShoulder #ENGvIRE #GuinnessSixNations pic.twitter.com/rdKGadYQQJ
— Irish Rugby (@IrishRugby) February 21, 2020